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SkinAid 4.0 Instructions for Use (04.08.2022)

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Please find older versions of Dermus SkinAid manual in the archive.

1. About SkinAid

SkinAid is a web application that allows the user to view optical and ultrasound image recordings and their associated metadata (lesion location, patient's year of birth, optional notes) that are both being anonymously stored on the Cloud. The web application allows the user to make annotations on the images. This helps in communication between the dermatologist and the colleague performing the treatment procedure. The image and the associated anonymous metadata can be shared by the dermatologist and accessed by a surgeon or operating dermatologist performing the treatment procedure, using a unique link and a password specified by the dermatologist performing the annotationor downloaded directly as a PDF file.

2. How to Start

The software is available at www.skinaid.app, where the user can sign in with a registered email address and a corresponding password.

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\uD83D\uDCD8 2.1. How to Register

If you are a new user, you can initiate your registration by selecting  the “Sign up” label either below the “Sign in” button or at the right side of the top bar. 

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Following  a successful verification, you will receive a confirmation email from Dermus Ltd, where you will be granted access to our SkinAid platform.

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\uD83D\uDCD8 2.2. How to Sign In 

After successful registration, you can log in to the SkinAid interface by providing your credentials and selecting the ‘Sing In’ button.

If you have registered before but you do not remember your password, you can click on the “Forgot password?” label and follow the instructions for resetting your password.

\uD83D\uDCD8 2.3. How to add a new patient

Following a successful login, the user can access the previously added (anonymous) patient data and can edit them, optionally.

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Info

Please note that a "Patient ID" numbers are generated automatically, to maintain anonymity of the patients.

\uD83D\uDCD8 2.4. How to add a new lesion

A single patient's page contains a general information of the patient (patient ID, birth year, sex, patient notes), access to previously added lesions, and a shortcut to add a new lesion.

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On the single lesion screen, the relevant region of the body schematic with the selected lesion location, the lesion note and the lesion diagnosis are shown alongside the primary patient information (patient ID, birth year, sex). This is the screen from which single recordings of the lesion can be opened or new recordings can be added in various ways and forms.

\uD83D\uDCD8 2.5. How to add a new recording

There are three ways of adding a recording to a lesion of a patient. All of them can be started by hovering over the “Ⓥ” button on a single lesion screen. 

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Selecting the other button (“Import OptoFuse record”) prompts the OptoFuse record uploading interface (see Section 4.1).

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\uD83D\uDCD8 2.6. How to navigate the Toolbar

At the top of the page, you can find the navigation Toolbar of the SkinAid Software as shown in the image below.

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Settings – a shortcut to the User related Settings page.

Logout button.

3. Recording-level User Interactions

On the screen of a single recording, you can find several tools for record analysis by hovering over the “Ⓥ”button at the bottom right corner of the page. 

The following tools can be found on the interface:

  • Segmentation

  • Annotation

  • Record Notes

  • Download images

  • Thickness Measurement

  • Record Information

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\uD83D\uDCD8 3.1. Segmentation

This function allows users to map a manual segmentation on the ultrasound image.

Info

 Please note that the automated segmentation is currently under development.

The segmentations can be outlined by polygon shapes superimposed on the existing ultrasound image. The polygons can be drawn with various colors, each representing a different skin structure. 

The corresponding colors and their structure types are shown at the top of the screen above the ultrasound image. In the cases of multimodal (optical + ultrasound image) recordings, the segmentation will be done on the ultrasound image. 

To add and customize a new polygon shape representing segmentation, the following steps are required:

  • Select the structure listed with ‘radio buttons’.

  • Add a new polygon by long clicking anywhere on the image and select “Add new polygon”. This adds a rectangle with 4 nodes.

  • Modify the shape of the polygon by holding and moving its nods one-by-one.

  • Move the whole polygon without modifying its shape by holding and moving the mouse at any point within the polygon.

  • To add a new node to the polygon, long click (for over 2 seconds) on the relevant line of the polygon (for over 2 seconds) and select “Add new point”.

  • To delete a node of the polygon, long click on the relevant node of the polygon (for over 2 seconds) and select “Delete point”.

\uD83D\uDCD8 3.2. Annotation

A dermatologist can mark out lesion borders or any other structures on a given image by using the annotation functionality of the SkinAid software.

Using the annotation functionality, you can highlight any points or structures of interest on the image (up to 7 points). You may also use this for highlighting the borders of a lesion as shown in the example below. Points are selected by single clicks at desired locations on the image. The green circles around the dots are intended to highlight the marked points more prominently. Point selections can be withdrawn by using the “Undo” button.

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It is possible to zoom into the image by scrolling the wheel of your mouse  for more precise marking. Click on ‘Save Annotation’ to save your image plot. When the Annotation is ready, the pdf report can be either sent to an email address or be downloaded directly.

\uD83D\uDCD8 3.3. Record notes

With this command, notes can be selected from a predefined drop-down list (See Figure 1). 

  • Multiple predefined text items can be selected in a single note. 

  • Each note will have its own time stamp and will be ordered according to the most recent date of creation.

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\uD83D\uDCD8 3.4. Download images

By selecting this option, the image(s) will be downloaded automatically. The image file name will contain patient ID, lesion ID and recording ID information. For OptoFuse recordings, both ultrasound and optical images will be automatically downloaded in separate files. 

Info

Please note that the browser may enquire a permission to download multiple files, when using this functionality for the first time.

\uD83D\uDCD8 3.5. Thickness measurement

This option allows users to make a distance measurement by selecting two points on the ultrasound image. Only vertical measurement is possible currently, which means that the output of the measurement will be the vertical (depth) projection (component) of the distance between the two points, making thickness measurements of skin layers with a parallel orientation to the surface easier. 

If a measurement was made, its point selection and results will be automatically saved as a record note (see Section 3.3). The record note contains the following values [mm]:

  • x1 – lateral coordinate of point 1 (first selected)

  • y1 – vertical (depth) coordinate of point 1 (first selected)

  • x2 – lateral coordinate of point 2 (second selected)

  • y2 – vertical (depth) coordinate of point 2 (second selected)

  • dx – lateral projection of the distance between the two points

  • dy – vertical (depth) projection of the distance between the two points

  • d – true distance between the two points

\uD83D\uDCD8 3.6. Record information

Record information is automatically created and can be viewed via selecting this button after a lesion segmentation was performed on the ultrasound (US) image of the record. In such case, the following information are calculated and displayed as “lesion measurements” in [mm]:

  • US lesion axis ratio,

  • US lesion compactness,

  • US lesion PA ratio.

4. OptoFuse Recording 

OptoFuse Recording is an optical-ultrasound image set with one optical image and multiple ultrasound images of the same skin area. In order to get a reliable fusion of the images, a specific physical marker (also presented on the images below) shall be used when recording optical and ultrasound images.

\uD83D\uDCD8 4.1. Importing OptoFuse Image

The “Import OptoFuse record” screen can be reached as described above, in Section 2.5.

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To import an OptoFuse recording to the software the following steps are required:

  1. Import optical Image by clicking on the ‘Upload’ sign. 

    Image Added
  2. Import ultrasound image set folder by clicking on the ‘Upload’ sign.

    Image Added

  3. Add ultrasound image depth in millimeters.

  4. Add ultrasound image width in millimeters.

  5. After providing all the necessary data, upload the files by selecting the‘Upload OptoFuse Record’ button at the bottom of the webpage.

Info

Please note the folder to be uploaded should contain images of the same and  size.

\uD83D\uDCD8 4.2. Handling Imported Records

After a successful import, the OptoFuse Recording will be displayed on the screen as shown in the image below.

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  • It is possible to  scroll between the imported ultrasound images by moving your mouse pointer above the ultrasound image vertically, while holding down the left mouse button for selection. 

  • The red line on the optical image indicates the spatial position of the ultrasound image slice that is on display. 

  • If you click on the ‘Show Segmentation’ button, the results of lesion segmentation will be demonstrated in detail (on the ultrasound image). The segmentation will be computed for all of the ultrasound images.

  • The results of segmentation can be converted into a depth map of the lesion which will be displayed on the optical image window after selecting the ‘Show Depth Map’  button. The map shows the depth dimension of the lesion projected onto the surface of the skin as derived from segmentation results of the ultrasound images. 

  • On the ultrasound image window, you can zoom into the images by scrolling the wheel of your mouse. Simultaneously, the red line follows the zooming command on the optical image window, indicating the relative position of the ultrasound image slice on the optical image of the surface of the skin. 

  • It is also possible to add notes to the recording by hovering over the “Ⓥ” button and selecting the ‘Notepad’ symbol on the right side of the screen as shown in the image below. 

  • By clicking on the ‘PDF report’ you can create a report in ‘.pdf’ format. When the report is ready, the report can be either sent to an email address or be downloaded directly.

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Info

Please note that the PDF file will contain anonymous patient information and lesion data. It also includes ultrasound, optical image pairs and their corresponding examination time and date.

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Please note that the images of the PDF file will include segmentation and/or depth map overlays captured at the time of selecting the ‘PDF report’ button. 

\uD83D\uDCD8 4.3. PDF report Generation

A report is created in PDF format, which can either be downloaded directly or forwarded to an email address.

Implementation

The report is generated in PDF format after clicking on the “PDF report” button for an optical-ultrasound (OptoFuse) recording or for a different type of saved annotation (containing a single image). 

There are two options to access the generated report, using the “Send or Download the report” pop-up window, which appears after pressing the “PDF report” button. 

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The user can type in an email address and send the report to that address by pressing the “Send” button.

  • The user gets notified with an error message if the given email address was incorrect.

  • If an existing email address was given, an email entitled “Report” is received on that address, containing the following sentence with a link clicking on which a new page is opened and the PDF report file gets downloaded automatically: “You can download the report here.“

  • The email also contains the following sentence: “Please note that the current report is not a standalone medical report, it can only serve as an attachment to an existing medical report.“

The user can download the PDF report directly by pressing the “Download” button.

Info

Please note that the progress of the PDF report generation is displayed in percentages. Downloading or email-sending starts only after generation reaches 100%.

If a report of the same recording is generated previously, a message in the “Send or download the report” pop-up window will show the following notification: 

“The report is already generated previously“.

Info

Please note that in the case of an existing report, a pop-up window with a “The report is already generated previously“ message will appear under “Send or download the report”.

Content of the PDF report

The file name of the report contains the following information:

  • Report

  • Patient ID

  • Lesion ID

  • Recording ID

  • Time stamp

The report contains the following:

  • Dermus company logo

  • SkinAid website address

  • Title: “Report”

  • Patient ID (non-identifiable)

  • Patient gender

  • SkinAid website address

  • Title: “Report”

  • Patient ID (non-identifiable)

  • Patient gender

  • Patient birth year

  • Diagnosis

  • Patient note

  • Lesion note

  • Record notes

  • Schematic image of lesion location

  • Images (see below)

  • Report ID

  • Warnings (see below)

    Images of the PDF report

    In the case of an annotated image:

    • image of lesion with annotation superimposed

    In the case of an Opto-Fuse recording:

    • Image pairs of optical and corresponding ultrasound images with ultrasound image slice marker on the optical image

    • The number of the image pair is displayed together with the total number of image pairs of the report

    In the cases of showing “depth map” when generating the report:

    • The optical images contain the depth map and the corresponding colorbar appears above the optical images

    In the cases of showing “segmentation” when generating the report:

    • The ultrasound images contain the segmentation overlay and the corresponding legend appears above the ultrasound images

    In the case of an annotated single optical-ultrasound image pair – if not less than 2 points are selected on the ultrasound image during the annotation:

    • axial thickness of the annotated area, with the following description: “The height difference between the two farthest annotation points is in millimeters”

Info

Please note that the annotation points are not only superimposed on the ultrasound image but also their projection to the plane of the optical image is superimposed on the optical image with a different color.

Warnings of the PDF report

  • “The current report is not a standalone medical report, it can only serve as an attachment to an existing medical report.”

  • “Marker-based optical-ultrasound fusion is currently under evaluation, do not use it for clinical purposes without a permit from the relevant Authorities.”

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